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Subissue of Cell： Discovery of Enterobacteria Degrading Uric Acid

2025年4月29日 | admin | C3

The original Singularity Cake Singularity Network is included in the collection # 62 Intestinal Microbes # 57 Cardiovascular Diseases.

* For medical professionals only.

It’s summer. Have you arranged all the beer skewers and juice in little seafood? Singularity cake every time I watch this kind of food electronic mustard tuber, the barrage will float past the "gout package!" Hmm … Everyone has a high awareness of health!

Foods such as beer, seafood and animal offal are rich in purines, and some purines, such as xanthine, hypoxanthine and uric acid, the final metabolites of purines, are considered as uremic toxins (wastes that patients with impaired renal function cannot metabolize normally) [1], which are related to some symptoms of chronic kidney disease [2].

It is also a typical symptom of gout that uric acid can not be metabolized normally, resulting in the formation of pro-inflammatory crystals deposited on joints. However, some studies have found that uric acid concentration within the solubility range can also promote atherosclerosis through AMPK pathway-mediated inflammation [3]. Isn’t the kidney working hard enough? However, intestinal microbes will shoot!

Recently, the research team at the University of Wisconsin-Madison found that intestinal microorganisms can affect the progression of atherosclerosis by regulating the level of uric acid circulation. They identified intestinal microorganisms that use purines such as uric acid as carbon and energy sources in anaerobic environment, as well as gene clusters encoding key steps of purine degradation. This is a potential new way for intestinal microorganisms to affect health, which may provide a new way for treating gout or preventing cardiovascular diseases. The research results were published in Cell, Host and Microorganism [4].

Previous studies have shown that the atherosclerosis burden of more than 100 inbred mice in the Hybrid Mouse Diversity Group (HMDP) is very different, and the composition of intestinal flora is also obviously different [5,6].

In this study, the researchers selected four kinds of HMDP, two of which showed obvious atherosclerosis (experimental group) and two of which showed almost no signs of disease (control group), transplanted their flora to aseptic APOE knockout mice (which could spontaneously form hypercholesterolemia and atherosclerosis) and fed them with a diet supplemented with 0.2% cholesterol for 8 weeks.

Compared with the control group, the pathological changes in the experimental group are obvious. Traditional cardiovascular risk factors such as body weight and cholesterol intake, as well as intestinal microbial metabolites lipopolysaccharide, trimethylamine -N- oxide (TMAO) and short-chain fatty acids can’t explain this difference.

Macrogenome analysis identified 1649 functional features and 52 bacterial taxonomic features, and correlation analysis identified several bacterial functions related to atherosclerosis load, including those related to purine production and transformation. Among the 682 metabolites in mouse plasma, purine metabolites, including xanthine, xanthine nucleoside, inosine and uric acid, are positively correlated with the size of atherosclerotic plaque.

Correlation between xanthine, xanthine nucleoside, uric acid and inosine and atherosclerotic plaque size

In the cohort of human volunteers, there is a significant positive correlation between coronary artery calcification (CAC) score and uric acid level, and several taxonomic units in Clostridium have a negative correlation with uric acid level, which may affect uric acid level.

Compared with conventional mice, most purine levels in cecum/feces of sterile mice decreased, and only uric acid and allantoin levels increased. Similarly, the level of uric acid in plasma of sterile mice also increased significantly. Therefore, intestinal microorganisms may be able to regulate the level of purine in intestine and whole body. This strengthened the researchers’ determination to isolate purine-degrading bacteria in the intestine.

Intestine is the key organ of purine homeostasis. Dietary purine is absorbed in the intestine, and intestinal microorganisms produce and recover purine needed for its anabolism. About 30% uric acid produced by body metabolism will be secreted into the intestine.

The researchers tried to enrich anaerobic bacteria on the culture medium with uric acid as the main source of carbon and energy by using human feces samples, and obtained several bacteria from Firmicutes and Proteobacteria, which were identified as Enterocloster bolteae and Escherichia coli by 16S rRNA sequencing. The model strain ATCC BAA-613 of Enterocloster bolteae was cultured in a medium supplemented with 12mg uric acid. 10ml of strain culture degraded 49.6μmol of substrate within 24 hours, and produced 106.9μmol of acetate.

Based on the success of this small-scale attempt, the researchers expanded the search for intestinal microorganisms with purine degradation ability, and identified 34 kinds of bacteria from 6 phyla by the same method. The purine utilization ability of different bacteria is different. For example, Escherichia coli MS200-1 and I-11 have stronger uric acid utilization ability than Escherichia coli K12. Allantoin can support the growth of Enterocloster bolteae and Escherichia coli, but it cannot support the growth of Clostridium difficile or Edwardsiella tarda.

Representatives of 34 kinds of bacteria

By comparing the conserved chromosome regions of these intestinal microorganisms, the researchers found that five genes (dpaL, hydA, ssnA, ygeY and xdhD) were conserved. Compared with the sterile mice with non-purine degrading flora and the sterile mice with conserved gene deletion mutant flora, the plasma uric acid level of the mice with wild-type strains was significantly lower. There was a negative correlation between the level of purine-related metabolites in cecum and the abundance of five genes in APOE knockout sterile mice. This shows that these genes and their encoded intestinal bacteria have the ability to regulate uric acid homeostasis in vivo.

Identification of conserved genes

Generally speaking, this study found a previously neglected factor affecting uric acid circulation level-intestinal microorganisms and the corresponding key genes. In the future, more research is needed to answer the effects of aerobic and anaerobic purine consumption pathways on purine and intestinal microecology, as well as atherosclerosis and other health conditions.

# Friends, in order not to miss the important research progress of Singularity Cake Push, be sure to add stars to us ~

References:

[1] Falconi C A, Junho C V C, Foga?a-Ruiz F, et al. Uremic toxins: an alarming danger concerning the cardiovascular system[J]. Frontiers in physiology, 2021, 12: 686249.

[2] Valkenburg S, Glorieux G, Vanholder R. Uremic toxins and cardiovascular system[J]. Cardiology Clinics, 2021, 39(3): 307-318.

[3] Kimura Y, Yanagida T, Onda A, et al. Soluble uric acid promotes atherosclerosis via AMPK (AMP-activated protein kinase)-mediated inflammation[J]. Arteriosclerosis, thrombosis, and vascular biology, 2020, 40(3): 570-582.

[4] Kasahara K, Kerby R L, Zhang Q, et al. Gut bacterial metabolism contributes to host global purine homeostasis[J]. Cell Host & Microbe, 2023.

[5] Bennett B J, Davis R C, Civelek M, et al. Genetic architecture of atherosclerosis in mice: a systems genetics analysis of common inbred strains[J]. PLoS genetics, 2015, 11(12): e1005711.

[6] Org E, Parks B W, Joo J W J, et al. Genetic and environmental control of host-gut microbiota interactions[J]. Genome research, 2015, 25(10): 1558-1569.

The author of this article should be Yu Yan.

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Pony Pentium long battery life version is priced at 3.69-3.99 million and has a battery life of 222km.

2025年4月27日 | admin | B2

A few days ago, the Pony Pentium Long Life Edition was officially launched, and the new car launched two configurations, priced at 36,900 and 39,900 respectively. As a new version, the design of the new car is consistent with that of the current model, and various color schemes are provided, including bubble blue car color+interior bubble blue, Tiandai green car color+interior Tiandai green, camellia green car color+interior peach powder+interior peach powder, cheese white car color+interior beach gold, jasmine white car color+interior beach gold, which meets the diverse aesthetic needs of young consumers.

In terms of interior, the new car is mainly upgraded for configuration, and the remote car control function can display more comprehensive car conditions, support remote air conditioning control and remote unlocking. In addition, the new car also comes standard with airbags, heating and cooling air conditioning, ramp assist, main driver’s cosmetic mirror, 5/5 rear seat, etc. At the same time, it also has building block space, 130mm ground clearance, IP68 battery dustproof and waterproof, etc.

In the power part, the long-life version is equipped with a driving motor with a maximum power of 20 kW and a peak torque of 85 Nm. In terms of battery life, the car’s pure electric cruising range is 222 kilometers. The slow charging port of the car is located under the central cover of the front face, and there is also a glass water filling port on the left side of the charging port.

Notice of the General Office of Hunan Provincial People’s Government on Printing and Distributing the Emergency Plan for Maritime Search and Rescue in Hunan Province

2025年4月26日 | admin | B2

　　General Office of Hunan Provincial People’s Government

　　Notice on Issuing the Emergency Plan for Water Search and Rescue in Hunan Province

　　Xiang Zheng Ban Fa [2015] No.99

Municipal People’s governments, provincial government departments and commissions, and directly affiliated institutions:

　　"Emergency Plan for Water Search and Rescue in Hunan Province" has been agreed by the provincial people’s government and is hereby issued to you, please earnestly organize its implementation.

　　General Office of Hunan Provincial People’s Government

　　November 19, 2015

　　Emergency plan for water search and rescue in Hunan Province

　　Catalogue

　　1. General principles

　　1.1 Purpose of compilation

　　1.2 Compilation basis

　　1.3 Scope of application

　　1.4 working principles

　　2. Emergency command system and responsibilities

　　2.1 emergency organization

　　2.2 responsibilities of emergency organization

　　2.3 Expert Group

　　2.4 on-site organization

　　3. Monitoring, early warning and information reporting

　　3.1 Monitoring and early warning

　　3.2 Information report

　　4. Emergency response

　　4.1 Event classification

　　4.2 Graded response

　　4.3 Emergency treatment

　　4.4 Information release

　　4.5 End of emergency

　　Step 5 deal with the aftermath

　　5.1 aftermath disposal

　　5.2 Investigation and evaluation

　　6. Emergency support

　　6.1 Team Support

　　6.2 Financial guarantee

　　6.3 Communication Guarantee

　　6.4 Material and technical support

　　7. Supervision and management

　　7.1 Publicity, training and drills

　　7.2 accountability

　　8. supplementary provisions

　　8.1 Plan Management and Update

　　8.2 Plan formulation and implementation

　　1. General principles

　　1.1 Purpose of compilation

　　Establish and improve the province’s emergency response mechanism for water emergencies, quickly, efficiently and orderly deal with water emergencies, minimize casualties and property losses, ensure safe and smooth water traffic, and maintain social stability.

　　1.2 Compilation basis

　　People’s Republic of China (PRC) Emergency Response Law, People’s Republic of China (PRC) Safety Production Law, People’s Republic of China (PRC) Inland River Traffic Safety Management Regulations, National Maritime Search and Rescue Emergency Plan, Hunan Province Emergency Overall Emergency Plan and other laws, regulations and relevant provisions.

　　1.3 Scope of application

　　This plan is applicable to the prevention and emergency search and rescue of emergencies in the field of transportation within the administrative area of this province (including navigable waters under the jurisdiction of our province and closed waters with operating ships).

　　1.4 working principles

　　The emergency handling of water emergencies follows the principles of people-oriented, prevention-oriented, unified leadership, graded responsibility, territorial-oriented, compartmentalized, standardized according to law and scientific decision-making.

　　2. Emergency command system and responsibilities

　　The people’s governments of provinces, cities, prefectures, counties and cities shall set up emergency command institutions for water search and rescue, and be responsible for the emergency handling of water emergencies within their respective administrative areas.

　　2.1 emergency organization

　　The provincial people’s government set up the emergency headquarters (hereinafter referred to as the provincial headquarters) for water search and rescue in Hunan Province, with the deputy governor in charge of the provincial people’s government as the commander, the deputy secretary-general of the provincial people’s government, the director of the provincial department of transportation, and the city governor of the people’s government of the city where the incident occurred as the deputy commander. Provincial local maritime bureau, Provincial Water Resources Department, Provincial Government Information Office, Provincial Development and Reform Commission, Provincial Safety Supervision Bureau, Provincial Public Security Department, Provincial Health and Family Planning Commission, Provincial Agriculture Committee, Provincial Water Resources Department, Provincial Civil Affairs Department, Provincial Environmental Protection Department, Provincial Press, Publication, Radio, Film and Television Bureau, Provincial Finance Department, Provincial Meteorological Bureau, Provincial Communications Administration, Civil Aviation Hunan Supervision Bureau, Provincial Military Command, Hunan Armed Police Corps, Provincial Fire Corps (Provincial Emergency Rescue Corps) and other units are members.

　　The provincial headquarters office is located in the provincial local maritime bureau, and the director of the provincial local maritime bureau concurrently serves as the director of the office.

　　2.2 responsibilities of emergency organization

　　2.2.1 Provincial Headquarters

　　Unified command and coordination of the province’s water emergency response and search and rescue operations; Organize emergency search and rescue operations, mobilize the required manpower and material resources to do related work; Make decisions and give instructions on emergency handling and search and rescue operations of water emergencies; Ask for help and support from the state and the water search and rescue headquarters of the brother provinces, autonomous regions and municipalities as appropriate.

　　2.2.2 Provincial Headquarters Office

　　Implement the arrangements of the provincial headquarters, and formulate the working procedures and working rules for emergency handling and search and rescue operations on water; Check and urge the relevant departments (units) to implement emergency measures; Record, report, report and summarize information related to water emergencies; To study and coordinate the specific problems of emergency handling of water emergencies, and take the lead in drafting the summary and evaluation report of water emergencies; Complete other tasks assigned by the provincial headquarters.

　　2.2.3 Member units of provincial headquarters

　　The Provincial Department of Transportation is responsible for the organization, command and coordination of emergency response and search and rescue operations, and provides necessary search and rescue resources and technical support; Responsible for coordinating professional and social rescue forces to participate in water search and rescue; Guide the work of the provincial headquarters office.

　　The provincial local maritime safety administration undertakes the daily organization, command and coordination of water emergencies; Call other operating ships and social rescue forces in the accident waters to participate in search and rescue; To undertake the daily work of the provincial headquarters office; Organize and coordinate emergency rescue work.

　　The Provincial Water Resources Department provides real-time hydrological data for emergency response, organizes water level dispatching in the incident basin, and participates in the organization and coordination of emergency response on water.

　　The provincial government information office is responsible for coordinating the information release and public opinion guidance of water emergencies.

　　Provincial Development and Reform Commission guides and deliberates the preparation of water accident prevention planning and supports the construction of water accident prevention projects; Formulate emergency relief material supply guarantee plan.

　　Provincial Safety Supervision Bureau participates in the organization, command and coordination of water search and rescue and emergency disposal of large-scale polluted waters by ships.

　　The Provincial Public Security Department organized public security marine police and boats to assist traffic, maritime and professional emergency rescue teams to carry out water search and rescue emergency operations; Responsible for traffic control and public order maintenance of major emergency search and rescue activities.

　　The Provincial Health and Family Planning Commission is responsible for coordinating the emergency medical rescue work for water emergencies.

　　The Provincial Agriculture Committee is responsible for providing fishing boats with distress information and technical support needed for water search and rescue; Responsible for organizing fishing boats near the scene of the accident to participate in water search and rescue emergency operations.

　　The Provincial Civil Affairs Department participates in the social assistance and aftermath of water emergencies.

　　The Provincial Environmental Protection Department participates in the organization, command, coordination and pollution disposal of emergency disposal of large-scale polluted waters by ships, and is responsible for providing environmental monitoring information of polluted waters and environmental protection technical support related to water pollution.

　　Provincial Press, Publication, Radio, Film and Television Bureau organizes and coordinates radio, television and radio stations to release information in a timely manner.

　　The Provincial Department of Finance is responsible for timely application, arrangement and disbursement of search and rescue funds and materials, and cooperate with relevant departments to supervise their use.

　　The Provincial Meteorological Bureau is responsible for meteorological information and technical support for water search and rescue.

　　The Provincial Communications Administration is responsible for the communication support for emergency rescue operations on water.

　　Hunan Civil Aviation Supervision Bureau is responsible for providing civil aircraft distress information and search and rescue technical support, and participating in the command and coordination of civil aircraft search and rescue.

　　The provincial military command is responsible for organizing and coordinating the troops stationed in Hunan and the militia reserve forces to participate in water search and rescue and emergency disposal of large-scale polluted waters by ships.

　　Hunan Armed Police Corps is responsible for organizing and directing the Armed Police Force to participate in the emergency response of water emergencies.

　　Provincial Fire Corps (Provincial Emergency Rescue Corps) is responsible for organizing and directing fire forces to participate in the emergency treatment of water emergencies.

　　2.3 Expert Group

　　The provincial headquarters set up an emergency expert group for water emergency search and rescue, which is responsible for providing decision-making consultation and technical support for the provincial headquarters.

　　2.4 on-site organization

　　2.4.1 Field headquarters

　　After the water emergency, the people’s government of the place where the incident occurred quickly set up the on-site command, and under the leadership of the provincial command, directed and coordinated the on-site emergency response work of water search and rescue. The on-site headquarters is located in the local maritime safety administration, and the person in charge of the local people’s government is the commander.

　　The main responsibility of the on-site command is to carry out the task of water search and rescue issued by the provincial command; Be responsible for putting forward specific measures and plans for emergency treatment; Carry out various on-site emergency disposal work.

　　2.4.2 Emergency Rescue Working Group

　　According to the needs of emergency response, the field command has several working groups.

　　(1) Information processing group: carry out the instructions of the headquarters, be responsible for the organization, command and coordination of the emergency search and rescue work site, and designate a command ship.

　　(2) Evaluation and judgment group: make a preliminary evaluation according to the development of on-site danger and the implementation effect of emergency response plan, and put forward opinions on adjusting emergency response measures or suggestions on ending emergency response actions.

　　(3) Logistics Support Group: guiding ships and facilities to organize self-help and mutual rescue; Responsible for mobilizing social assistance forces to participate in emergency rescue.

　　(4) Emergency Action Team: When the dangerous situation changes sharply, it has the right to take relevant reasonable actions on the premise of ensuring to reduce casualties and economic losses of the accident and reduce water pollution.

　　(5) Monitoring and monitoring group: responsible for monitoring and monitoring the dangerous situation at the emergency search and rescue site, reporting the situation at the site or asking for emergency matters.

　　(6) Security guard group: responsible for on-site traffic control and maintaining navigation order.

　　(7) Aftercare team: responsible for organizing, coordinating and directing the work of clearing and evacuating the site, and doing a good job in aftercare.

　　3. Monitoring, early warning and information reporting

　　3.1 Monitoring and early warning

　　Water search and rescue agencies at all levels should strengthen the investigation, analysis and registration of dangerous sources and dangerous areas that may cause water emergencies in the waters under their jurisdiction in combination with daily management, organize risk assessment, determine the risk level, and timely notify the local people’s government. Relevant units should formulate preventive measures and strengthen daily monitoring and inspection according to the hazard sources, risk levels and nature of water emergencies.

　　Early warning information monitoring departments shall, according to their respective responsibilities, release early warning information of meteorological, hydrological and geological disasters to relevant parties through information broadcasting channels. Early warning information generally includes meteorological, hydrological, geological and other natural disaster forecasting information and other information that may trigger water emergencies.

　　3.2 Information report

　　3.2.1 Reporting procedure

　　When the personnel on duty find a dangerous situation or receive an incident report, they should immediately contact the relevant departments at the place where the incident occurred, quickly confirm the nature and grade of the water emergency, and report to the superior emergency agency in time.

　　3.2.2 Report content

　　The report of water emergency information should be fast and accurate, including the following contents:

　　(1) the time and place of the incident;

　　(2) the number of casualties, economic losses, damage degree, etc.;

　　(3) Relevant information about the ship and its subordinate units;

　　(4) The brief course of the incident and the current disposal situation;

　　(5) Other relevant matters that need to be reported.

　　4. Emergency response

　　4.1 Event classification

　　According to the degree of harm to life safety and water environment and the development trend, water emergencies are divided into four levels: general (IV), major (III), major (II) and particularly major (I).

　　4.1.1 A general water emergency (Grade IV) meets one of the following conditions: less than 3 people fall into the water to be rescued or less than 10 people are in distress; Accidents (hereinafter referred to as accidents) such as collision, hitting rocks, fire, contact damage, grounding and windstorm of ordinary cargo ships below 300 gross tons pose a threat to the life safety of ships and personnel; The oil spill from the ship is less than 5 tons.

　　4.1.2 A major water emergency (Grade III) meets one of the following conditions: more than 3 people and less than 10 people fall into the water to be rescued, or more than 10 people and less than 30 people are in distress; Accidents of ordinary cargo ships with a gross tonnage of more than 300 tons and a gross tonnage of less than 1,000 tons pose a threat to the life safety of ships and personnel; The oil spill from the ship is more than 5 tons and less than 20 tons.

　　4.1.3 A major water emergency (Grade II) meets one of the following conditions: more than 10 people and less than 30 people fall into the water to be rescued, or more than 30 people and less than 60 people are in distress; Accidents of ordinary cargo ships with a gross tonnage of more than 1,000 tons and less than 3,000 tons pose a threat to the life safety of ships and personnel; The oil spill from the ship is more than 20 tons and less than 100 tons.

　　4.1.4 A particularly serious water emergency (Grade I) meets one of the following conditions: more than 30 people fall into the water to be rescued, or more than 60 people are in distress; Accidents of ships with a gross tonnage of more than 3,000 tons pose a threat to the life safety of ships and personnel; The ship spilled more than 100 tons of oil.

　　In the above quantitative expressions, "above" includes the number, and "below" does not include the number.

　　4.2 Graded response

　　4.2.1 Level IV response

　　In the event of a general water emergency, the county-level water search and rescue emergency headquarters immediately launched a level IV response, organized the implementation of emergency search and rescue, and quickly reported the relevant situation to the city-level water search and rescue emergency headquarters.

　　4.2.2 ш level response

　　In the event of a major water emergency, the city and state water search and rescue emergency headquarters immediately launched a class ш response, organized the implementation of emergency search and rescue, and quickly reported the relevant situation to the provincial headquarters.

　　4.2.3 Level II response

　　In case of a major water emergency, the provincial headquarters immediately launched a Class II response, and each member unit quickly carried out emergency search and rescue operations according to the instructions of the provincial headquarters and the responsibilities specified in the plan, and timely reported the relevant information to the National Maritime Search and Rescue emergency headquarters.

　　4.2.4 Level I response

　　In case of particularly serious water emergencies, the provincial headquarters shall report the development of water emergencies and the emergency situation of search and rescue to the provincial people’s government and the National Maritime Search and Rescue Center in a timely manner, and draw the National Maritime Search and Rescue Center to start a Class I response, and the provincial headquarters shall conduct emergency search and rescue under the guidance of the National Maritime Search and Rescue emergency headquarters.

　　4.3 Emergency treatment

　　After the dangerous situation occurs, the emergency command organization of water search and rescue at the incident site should immediately take measures to control the development of the situation, organize the pre-disposal work such as search and rescue, and report the development of the situation in a timely manner according to regulations. The relevant person in charge of the local people’s government immediately rushed to the scene, set up an on-site command organization, organized and directed the departments of transportation, maritime affairs, public security, fire protection, medical and health care to carry out emergency response, and took the following measures according to the actual situation:

　　(1) according to the specific location or possible location of the search and rescue target, determine the search and rescue area.

　　(2) To formulate the specific rescue plan on site and organize its implementation, and implement it after it is approved by the superior headquarters if necessary.

　　(3) According to the actual situation on site, several emergency response teams were set up to provide rescue.

　　(4) Organize and direct rescue forces at or near the scene of the incident, designate appropriate search and rescue methods for the rescue forces at the scene, assign search and rescue tasks, organize search and rescue operations, and ensure their safety at the same time.

　　(5) Quickly organize on-site treatment and transfer of the wounded.

　　(6) Fully understand and master the site situation, determine the site contact information, keep in touch with the superior headquarters, and feed back the site information in time.

　　(7) Make detailed records of on-site search and rescue operations, including on-site rescue forces and equipment, accidents or dangerous situations, search and rescue, etc.

　　(8) In case of pollution, sampling and evidence collection shall be organized and confirmed by the parties concerned.

　　(9) According to the change of site conditions, determine the use plan of rescue forces, and make suggestions on the emergency rescue plan formulated by the superior headquarters.

　　(10) Responsible for maintaining the order at the scene and dealing with the aftermath.

　　4.4 Information release

　　Water search and rescue emergency command institutions at all levels shall, in accordance with the relevant provisions of the Emergency Plan for Emergency News Release in Hunan Province, do a good job in information release.

　　4.5 End of emergency

　　After ships, facilities, aircraft or personnel are out of danger or pollutants have been effectively controlled and removed, the emergency response is declared to be over according to the principle of who started and who terminated.

　　Step 5 deal with the aftermath

　　5.1 aftermath disposal

　　The local medical and health department is responsible for the rescue of the injured; The local civil affairs department is responsible for the resettlement and rehabilitation of the rescued and dead, and organizes social assistance; The Hong Kong, Macao and Taiwan Affairs and Overseas Chinese Affairs Department of the local people’s government is responsible for the resettlement of Hong Kong, Macao and Taiwan nationals and foreign casualties.

　　5.2 Investigation and evaluation

　　After the rescue and disposal of water emergencies, the office of the water search and rescue emergency command organization shall, jointly with the member units of the command organization and the people’s government at the place where the incident occurred, investigate and summarize and evaluate the incident, and submit the summary and evaluation report to the people’s government at the same level and the superior water search and rescue emergency command organization.

　　6. Emergency support

　　6.1 Team Support

　　The professional teams of city and state water search and rescue and the water forces stationed in Hunan are the pre-disposal teams of water search and rescue emergency operations, and the professional emergency search and rescue teams of provincial water emergency search and rescue bases are the follow-up disposal teams, and request reinforcements to the National Maritime Search and Rescue Center and the water search and rescue emergency command institutions of neighboring provinces, autonomous regions and municipalities as appropriate.

　　6.2 Financial guarantee

　　The people’s governments at or above the county level shall include the emergency funds for water search and rescue in the financial budget.

　　6.3 Communication Guarantee

　　The offices of water search and rescue emergency command institutions at all levels shall establish an emergency address book for water emergencies, clarify the contact information, and strengthen the contact between member units and relevant departments and units.

　　6.4 Material and technical support

　　People’s governments at all levels and their relevant departments shall do a good job in emergency material reserve according to relevant laws and regulations, establish and improve the emergency material reserve network, allocate and update the emergency distribution system, and ensure the materials needed for emergency; Establish emergency equipment type, quantity, performance, storage location and standby system; Organize relevant scientific research institutions to carry out technical research on the development trend of water emergencies in our province.

　　7. Supervision and management

　　7.1 Publicity, training and drills

　　People’s governments at all levels, transportation departments and water emergency search and rescue headquarters should increase the publicity of emergency laws and regulations on water emergencies, prevention of hedging, self-help and mutual rescue, and strengthen the business training of staff of water search and rescue institutions and professional rescue forces on water search and rescue, so that they can master the knowledge and skills of water emergency search and rescue.

　　Emergency command agencies for water search and rescue at all levels should organize emergency drills regularly or irregularly, further clarify the responsibilities of each post in emergency response, and timely revise and improve the plans in view of the problems and deficiencies in the plans.

　　7.2 accountability

　　Units and individuals who do not perform their duties conscientiously, neglect their duties and cause serious losses shall be given corresponding punishment according to law; Those who violate the law shall be investigated for legal responsibility according to law.

　　8. supplementary provisions

　　8.1 Plan Management and Update

　　According to the actual situation, the Provincial Department of Transportation promptly submitted to the provincial people’s government to revise and improve this plan.

　　8.2 Plan formulation and implementation

　　This plan shall come into force as of the date of promulgation.

Let the breeze be healthy and full of common prosperity. Zhejiang explores the construction of a clean culture construction system in the new era

2025年4月21日 | admin | D4

　　In recent years, Zhejiang has conscientiously implemented the Opinions of the CPC Central Committee on Strengthening the Construction of a Clean and Honest Culture in the New Era, given full play to Zhejiang’s advantages as a pioneer in the construction of a clean and honest culture, strengthened the provincial top-level design of the construction of a clean and honest culture, focused on launching the brand of "Zhejiang Li Lian Feng", adhered to being close to reality, life and the masses, focused on the masses’ sense of identity, responsibility and acquisition of a clean and honest culture, and innovatively constructed an interactive expression matrix of mass clean and honest culture. Improve the reach and effectiveness of clean culture, cultivate the party style and political style, promote the folk customs and social style with the breeze and righteousness, promote clean and honest to become a common value concept followed by cadres, the masses, the industry and the society, and promote common prosperity.

　　Since May, scenic spots in Jingning She Autonomous County of Lishui City have ushered in a tourism boom. At the scene of the duet of She songs on the theme of honesty in the "China Window of She Township" scenic spot located in Dajun Township, dozens of She people dressed in festive costumes sang classic incorruptible songs in She language, such as "Persuading the World Song", "She Chanting Integrity" and "Twenty Articles on the Red Line of Performing Duty". While comparing the lyrics cue cards, tourists learned to sing the She folk songs on the theme of honesty with the She people, and "the most dazzling She Lian Feng" detonated the audience.

　　In combination with various forms of folk cultural activities, the Supervision Committee of the Commission for Discipline Inspection of Jingning County has launched a cultural package of "Journey to the Clear Wind" which integrates "She Taste" and "Lian Taste", bringing visitors an audio-visual feast full of "She Lian" elements. Tourism resources make clean culture full of vitality, and clean culture enriches the spiritual connotation for tourism development. Nowadays, it is becoming a new trend for all parts of Zhejiang to integrate clean culture into urban landscapes and cultural tourism attractions, and to create a "cheap tour" that integrates tourism, leisure and education.

　　Integrity culture is an important measure to enrich the spiritual world of the masses and promote spiritual wealth with honesty and culture, and it is the proper meaning of common prosperity. Zhejiang gives full play to the advantages of building a clean and honest culture, and takes strengthening the clean and honest culture construction as an important content into the key work runway of building a common prosperity demonstration zone, so as to achieve overall coordination, systematic planning, overall promotion, integrity and innovation, and explore and build a clean and honest culture construction system with distinctive Zhejiang characteristics in the new era, so that the clean and honest culture construction will be closer to reality, life and people, and continue to polish the "golden business card" of clean and honest culture with provincial recognition and national influence.

　　"Moisten things silently"

　　Integrate into the daily sharing of cool breeze and beautiful scenery

　　Yongjia County Commission for Discipline Inspection and Supervision has continuously enriched the carrier of clean culture and cultivated "Qingfeng ‘ Jia ’ Live broadcast room "brand, online and offline to carry out integrity education simultaneously, and constantly enhance the influence and penetration of integrity education. The picture shows that recently, the young discipline inspection and supervision cadres in the county are in "Qingfeng ‘ Jia ’ The live broadcast room tells the story of a clean family style. Photo by Gray

　　In Jiande Service Area of Hangzhou-Hangzhou Expressway, there are cheap, easy-to-buy, pure-meaning courtyard and Qingyi exhibition hall, which are full of cheap flavor and unique. This is the first incorruptible theme expressway service area created by Hangzhou Commission for Discipline Inspection and Supervision and Hangzhou Jiaotou Group — — "Lian Yi @ Home" is a fusion of clean culture, which provides public services such as shopping, leisure and culture for visitors from all directions, while strengthening the mass attribute of clean culture.

　　Focusing on the characteristics of "Zhejiang flavor" and "times", Zhejiang strengthens the top-level design, plans and integrates resources as a whole, adheres to the concept of co-construction and sharing, integrates the construction of clean culture into the overall planning of public cultural services, and transforms clean culture into a daily element that the broad masses of cadres and people can see and touch, and constantly enhances the appeal and penetration of clean culture.

　　Zhejiang is rich in traditional culture and red revolutionary culture. To this end, Zhejiang integrates and revitalizes clean cultural resources, builds a multi-level and classified clean cultural position system in the whole province, and establishes a clean cultural matrix of "one place, one product, and features online and offline" to aggregate clean centripetal force with position radiation.

　　At the provincial level, the provincial law and discipline education base, led by the Provincial Commission for Discipline Inspection and Supervision, which is jointly built by provinces and cities, has become an important place for party member cadres to receive warning education. Since its establishment in 2003, the provincial law and discipline education base has received more than 490,000 cadres from party member. Discipline inspection and supervision organs in various places use their brains to find ways to create clean and honest cultural positions in combination with local cultural resources, such as the Qingfeng Garden in Cicheng, Ningbo, the Honglian Museum in Nanhu, Jiaxing, and the "Shili Qingfeng" clean and honest cultural corridor in Lishui & HELIP; … A number of clean and honest cultural positions with local characteristics have sprung up like mushrooms after rain. With the red revolutionary culture, advanced socialist culture and excellent Chinese traditional culture as the cornerstones, Zhejiang has built a full coverage and socialized clean and honest cultural base from the bottom up. At present, there are over 400 clean and honest cultural education bases in the province, including 2 national clean and honest education bases and 50 provincial clean and honest cultural education bases with a construction area of over 1 million square meters.

　　At the same time, the Supervision Committee of the Zhejiang Provincial Commission for Discipline Inspection encourages all localities to promote the digitalization and informationization of the resources of clean and honest culture positions, and improve the accessibility and accessibility of clean and honest culture. Jindong district, Jinhua City gathers clean positions in the whole region to create a "clean map", and you can follow the video "Cloud Punch" for 12 clean micro-landmarks in the whole region in just half an hour with your fingers. Zhuji City has developed and launched the application of "Clean Wind and Clean Road in the New Era" on the platform of "Zheli Office" and WeChat applet. Taking "Clean Culture+"as the starting point, it integrates the modules of "Literature, Travel, Production and Learning" to provide more immersive online and offline clean education services for cadres and the masses.

　　"Through the combination of literature and tourism, culture and education, and digital integration, we will always deeply integrate the culture of honesty into social life and avoid the emergence of ‘ Stiff indoctrination ’ Phenomenon, constantly expand the popular attributes of clean culture, make clean culture alive and use, and continue to create a social atmosphere that is proud of honesty and beautiful. " The relevant person in charge of the Zhejiang Provincial Commission for Discipline Inspection said.

　　"To have a source of living water"

　　Do everything to moisten social cells.

　　In Lin ‘an District of Hangzhou, the incorruptible elements in the seal culture were deeply excavated, and the incorruptible education activities of "building a clean seal" were carried out, and young cadres in the area were organized to engrave an exclusive seal with their own names, making a promise of "performing their duties first" and planting the concept of incorruptibility with a full sense of ceremony. The picture shows the young cadres in Changhua Town, Lin ‘an District cherish their "clean seal" and promise "clean promise". Ren Xiaodong

　　Strengthening the construction of a clean and honest culture requires both spring rain-like infiltration and strong and effective education and guidance. In recent years, the discipline inspection and supervision organs at all levels in Zhejiang Province have paid attention to strengthening the education of honesty, especially giving play to the infiltration function of honesty and family style, highlighting the key object of party member cadres and families, and amplifying the demonstration effect of honesty and family style.

　　"As a member of the family, it is my duty to urge my husband to be honest and self-disciplined. I should not only be a good wife in the family, but also be a good one ‘ Secretary of the Family Discipline Inspection Commission ’ 。” Not long ago, a family member of a township cadre shared her experience at the scene of the clean family style education activity for the spouses of leading cadres in Cangnan County, Wenzhou City. The Supervision Committee of the Commission for Discipline Inspection of Cangnan County organized a series of clean education activities, such as "the breeze enters the house", in combination with the opportunity of selecting civilized families and "five good" families, to educate party member cadres to strengthen the consciousness of "supporting their families with honesty" and build a family defense line against corruption and change.

　　In order to make the family "cells" clean and promote the social "body" clean and honest, and to support the whole society with the good family style of thousands of families in Qian Qian, all parts of Zhejiang have actively explored. Taizhou initiated the "Clean Family Evaluation Index Table", which refined the evaluation content into 14 secondary evaluation modules, and carried out a two-way evaluation of "positive investigation+reverse investigation" to improve the effectiveness of family style construction. Lishui City fully tapped the family style allusions of revolutionary ancestors and historical sages in southwest Zhejiang, and displayed good stories of family style training in various places in the form of videos, cartoons, texts, etc., and vigorously promoted "clean family style" with the theme education activities of "promoting clean family style and building the most beautiful family". The Supervision Committee of the Commission for Discipline Inspection of Ninghai County, Ningbo City, together with the Working Committee of the county-level organs, the county women’s Federation and other departments, launched a list of "three disclosures" and a cartoon reminder card of "Ten Must Ask" to guide the families of cadres in party member to consciously guard the "happiness gate".

　　Focusing on the youth group, at present, the "Qing" cheap talk show is booming all over the province, with unconstrained script conception, exquisite on-the-spot response and skillful rhythm control. Young people from all walks of life talk about "incorruptibility" and present the discipline rules with humorous language and interesting expression. In the new era, young people’s unique ideas and novel opinions on "honesty" are realized through learning and speaking, which inspires young people to be honest and self-disciplined, and sets off an upsurge of young people saying, learning and respecting honesty.

　　Honest culture is not a lofty and lofty "spring snow". Zhejiang continues to deepen the connotation and extension of honest culture, allowing honest culture to infiltrate values and moral concepts, promoting the establishment of the ethos of advocating honesty as a cultural rule to be followed by the whole society, and further exerting the important role of honest culture in purifying social customs and conserving grassroots political ecology.

　　In Tiantai County, the birthplace of Chinese "Hehe Culture", the Supervision Committee of the County Commission for Discipline Inspection has continuously decoded Hehe gene, refining the clean concept of "clear distinction between public and private, fairness and decency, people-oriented, doing more practical things, paying attention to honesty and indifferent to fame and fortune". Nowadays, the friendly and gratifying cartoon image of "Harmony and Honesty" welcomes visitors from all directions in beautiful countryside. The propaganda group of "Harmony and Breeze" goes to the village to send "Honesty" to the door, and "Harmony and Breeze" permeates the grass-roots social governance, giving birth to a number of "golden ideas" that serve social production and life, such as letters and visits, mediation, teams and neighbors, and the culture of harmony and harmony nourishes the politics with a clean atmosphere.

　　"Fly into the homes of ordinary people"

　　Close to the masses and strive to create quality products of the times.

　　The Supervision Committee of the Commission for Discipline Inspection of Yunhe County strengthens the publicity of clean culture by touring the grassroots exhibitions of clean works and compiling theme publications, so as to create a good atmosphere of honesty, morality and honesty, and guide the broad masses of cadres and people to respect, think and keep clean. The picture shows the children of Yunhe County Experimental Primary School reading the publication on the theme of clean culture. Photo by zhangqian

　　On April 8th, under the guidance of the Supervision Committee of Ningbo Commission for Discipline Inspection, the clean and honest Yue opera "Walking the Horse and Imperial History" produced by Ningbo Performing Arts Group and performed by Ningbo Xiaobaihuayue Troupe was staged at the National Grand Theatre. It is reported that "The Imperial History of Walking Horse" has been on the road of public performance. Two months ago, the breeze of Ningbo Imperial History Culture blew to the edge of the desert, giving the people of Kuqa, Xinjiang a clean and honest cultural feast with modern aesthetics.

　　How to make the culture of honesty more vital? Only by integrating into the grassroots, approaching the masses and deepening the hearts of the people. Zhejiang has always adhered to the people’s position, guided by meeting the people’s demand for a clean culture, insisted on using people’s well-known figures and stories to create works, activated the historical genes of clean culture, expanded the era meaning of clean culture, and provided high-quality works that infiltrated the heart and inspired the mind, so as to keep pace with the times, resonate with the people, and enhance the people’s stickiness in the supply of clean culture.

　　Zhejiang Xiaobaihua Yue Opera Troupe is well-known among the fans of Yue Opera all over the country. Keqiao District of Shaoxing City has made full use of the advantages of "the hometown of opera" to arrange a clean and cultural boutique drama "One Money is the Taishou", which has toured the whole country and the whole province. With the story of Yu Qian, one of the "three outstanding figures in the West Lake", as the core, Hangzhou created the burlesque "Clear in White", and qingtian county created the Yue Opera "Liu Ji’s Return to the Native" based on the well-known story of Liu Bowen pleading for the people, and so on. Many works were selected for the projects funded by Zhejiang Culture and Art Development Fund, and the quality of clean culture showed a trend of blooming.

　　To play the role of clean culture in building consensus, enhancing identity and expanding influence, it is necessary to stimulate more social subjects to join in the creation and dissemination of clean culture and create an atmosphere of co-construction and sharing. All localities combine local realities, connect historical traditions, and tap local characteristics to find expressions that conform to the rhythm and aesthetic taste of modern society, promote the integration of clean culture in the new era with film and television, drama, literature, calligraphy, crafts, art and other fields, explore new paths for the spread of clean culture in the 5G era, and help clean culture "go out of the circle".

　　As an incorruptible cultural brand competition with distinctive Zhejiang recognition and national influence, the participants of the "Jade Cong Cup" incorruptible micro-film micro-video contest come from all walks of life all over the country. The newly set national college competition area has received 441 works from 58 colleges and universities, which fully stimulated the creative enthusiasm of college students. After the launch of the national call for papers for the 6th Lotus Cup Integrity Story Competition, it attracted the support of writers, workers, cadres, teachers, entrepreneurs, retirees and other groups, including Zi Jinchen, winner of Mao Dun Newcomer Award, He Changzai, winner of Mao Dun Literature Newcomer Award, and Qi Yingjun, an online writer.

　　Judging the winning works does not mean the end of the competition, but the process of taking root and sprouting clean seeds has just begun. Zhejiang continues to create a new paradigm of incorruptible cultural communication, and more and more incorruptible cultural works with cultural thickness, emotional temperature and ideological depth are inserted with innovative wings and fly into the homes of ordinary people. China Dam, an award-winning micro-film in the 3rd "Jade Cong Cup" Clean Micro-film Micro-video Competition, has completed the project of cinema film, which is a new attempt to open clean cultural products to the market. Not only that, in 2022, the fourth Qingfeng Cinema established by "Jade Cong Cup" and the first "Qingfeng Cinema" outside Zhejiang Province were listed in Anhui Sports Vocational and Technical College, and the previous "Jade Cong Cup" award-winning works were broadcast in the cinema in the form of public welfare, with better audio-visual effects. Continue to spread the energy of clean culture to cadres and the masses.

　　"The construction of a clean and honest culture in the new era is a systematic project that lays the foundation and benefits the long-term. It must be a long-term effort and unremitting efforts." The relevant person in charge of the Supervision Committee of the Zhejiang Provincial Commission for Discipline Inspection said that Zhejiang will carry forward the first demonstration of socialist cultural development, continue to strengthen the construction of a clean culture, and let the breeze fill the road of common prosperity.

　　(website of Zhejiang Provincial Commission for Discipline Inspection)

Is the frequent quality problems of Lexus behind the shutdown of CT200h the main reason？

2025年4月20日 | admin | A1

　　As early as many years ago, in order to make up for the shortcomings of Toyota’s high-end brand Lexus in compact models, CT200h was introduced to enhance its overall competitiveness. However, according to the sales data, from the launch of the CT200h to the first quarter of this year, the global cumulative sales volume is only about 267,000 vehicles. In this big market of China, the sales volume of the CT200h accounts for less than 10% of the total sales volume of Lexus. It can be seen that this entry-level car, which has been launched for nearly six years, has not brought surprises to Lexus.

　　▲ The sales volume is not satisfactory, and the production of CT200h is discontinued.

　　Perhaps the sales volume is not satisfactory. According to reliable sources, the CT200h will face production suspension, and Alain Uyrrenhoven, president of Lexus Europe, revealed that "the CT200h will be replaced by a hybrid small SUV". Of course, if we study why the CT200h stopped production according to the meaning of Lexus, we may only think that the SUV market is overheated and the cars are not popular, but is this really the case?

　　As we all know, compared with British finidi and Acura, Lexus, as a member of Japanese luxury Three Musketeers, has performed strongly in the market with its excellent quality and good service. Therefore, when the compact car CT200h, which started at more than 200,000 yuan, was launched, many people began to worry that it would more or less destroy the long-standing good image of Lexus.

　　▲ Hidden quality hazards affect the brand image, or become the main reason for the shutdown of CT200h.

　　Because it is a hybrid of oil and electricity, CT200h is excellent in fuel economy, and its bold design also shows the charm of Lexus. However, in details, CT200h really proves the truth of "a penny gets a share". First of all, in terms of materials, CT200h’s materials are very general, the suspension is hard and the comfort is average.

　　A criticism that is particularly worth mentioning is the sound insulation effect of CT200h h. It has been reported by the media that when the speed reaches above 80km/h, the noise inside the CT200h is as high as 79dB(70-90 dB is noisy and nerve cells are destroyed), which has seriously interfered with the driver’s driving and the safety hazard is very obvious.

　　In addition, a friend of Xiaobian’s car owner said that the CT200h he was driving had many problems, especially the abnormal brake noise. When Xiaobian searched online for the abnormal brake noise of CT200h, there was almost a buzz on the Internet. What’s more, some car owners couldn’t wait to show the abnormal brake noise in less than three or four days, which was really a headache.

　　Therefore, Xiao Bian guessed that the CT200h had the idea of stopping production because of its poor sound insulation effect and abnormal sound, which was not conducive to the establishment of a good brand image.

　　▲ frequent and numerous recalls, but ineffective and negative?

　　Originally, I wanted to fill the gap in the compact car market. Clinker CT200h, an entry-level model, did not give force, did not bring surprises to Lexus, and more or less brought some panic. So, is it the best choice to stop production of CT200h to reverse Gankun and re-establish the brand image?

　　In fact, in view of the defects of vehicles, car companies will start a recall plan to improve the problems of vehicles. Although Lexus has not implemented a recall for abnormal noise, Lexus has started a recall plan before because of the hidden dangers of fuel leakage and airbags, involving 37,423 vehicles, including CT200h.

　　The number of recalls is amazing, but this is not the problem of this recall. Xiaobian asked the owner’s friend. When he told him that his CT200h was going to be recalled for inspection and maintenance, he said he didn’t know. When he called the local 4S shop, the staff of the 4S shop admitted that his vehicle needed to be recalled. In other words, even if Lexus started the recall plan, it did not take the initiative to contact the owner for inspection and maintenance, but the owner reflected that the 4S shop admitted it. Does such a poor and negative service attitude really come from Lexus?

　　Coincidentally, another incident deserves our attention. A car owner once made a complaint on the car complaint network. He said that his newly bought 2014 lexus ES300 had just driven for 200 kilometers when the ABS fault light called the police, and the brake pedal didn’t respond at all. He was asked to replace the ABS controller assembly after going to the 4S shop for inspection.

　　The description of this problem coincides with the reason stated in Lexus’ recall regulations in April this year. The recall was as follows: due to the manufacturing reasons of a specific supplier, the oil pressure required for braking anti-lock braking system (ABS) and body stability control system (VSC) may not be provided normally, which may affect the driving stability of the vehicle and have potential safety hazards, and a total of 15,322 lexus ES200, ES250 and RX200t vehicles were recalled.

　　Putting the owner’s complaint together with the Lexus recall, we found that the owner’s ES300 also had the problems mentioned in the recall, but the ES300 was not within the scope of the recall!

　　Summary:Now, due to various quality problems, the CT200h is already in water under the bridge, and it has to stop production on the pretext of "good SUV market prospects". Apart from the tragic product CT200h, the frequent recalls of Lexus this year and the large number of them are really unsightly, but the negative and ineffective behaviors such as not notifying the owners in time and incomplete recalls are the facts that it is difficult to cover up when CT200h stops production.

Hunan Xiaomi SU7 brake failure？ Xiaomi PR admitted： It is indeed a software misidentification.

2025年4月19日 | admin | C3

According to the client news of Southern Metropolis Daily, on May 13th, the media reported that a few days ago, Mr. Li, the owner of a Xiaomi SU7 in Hunan, reported that during the parking process of his newly purchased millet SU7, the brakes were suspected to suddenly fail, the brake pedal had no damping feeling, and an alarm sounded in the car, and four abnormal messages such as "brake system failure" appeared. In addition, Mr. Li said that after the fault occurred, he called the Xiaomi car online service hotline for nearly half an hour, then called the SOS emergency call system and was transferred to the emergency road rescue center, but no one answered.

Mr. Li said that after more than an hour, the car was dragged back to a Xiaomi car delivery center in Changsha overnight, and the staff worked overtime to check. The next day, the feedback was that the brake electronic software was misjudged. And when the car arrives at the delivery center, the fault has been automatically eliminated.

On the afternoon of May 13th, Wang Hua, general manager of the public relations department of Xiaomi Group, publicly responded to this matter in Weibo. Wang Hua admitted that after verification,"It’s really a software misrecognition.".

Wang Hua said that it was confirmed by the analysis of the engineers of the automobile department that the reason for the failure was that the vehicle was at that time.The system of the master brake controller (DPB/BCP) mistakenly identifies the degradation and triggers the backup braking strategy., the auxiliary brake controller (ESP/BCS) directly responds to the braking demand to provide braking deceleration for the vehicle; At the same time, the big screen of the vehicle also reported the fault prompt of the braking system.

The "insufficient foot feel" reflected by Mr. Li is because in the above process, the vehicle entered the standby strategy of the braking system, and ESP pumped DPB brake fluid to increase the braking pressure for the wheels and let the vehicle brake; As the brake fluid is pumped from DPB by ESP, the pressure in the master cylinder of the brake decreases rapidly. It is precisely because the brake system is switched for the first time that the pressure in the cylinder of the original master brake is 0.

However, Wang Hua said that this does not mean that all braking force is lost. At this time, ESP intervened in braking, and there was no complete failure of the braking system and the loss of control of the vehicle.

Wang Hua pointed out that the braking system of SU7 is designed by using the double backup mechanism of DPB+ESP, and Xiaomi Automobile official micro-answered the questions of netizens on May 3.

Nandu Wancaishe reporter inquired about Xiaomi Automobile official micro-understanding that Xiaomi SU7 is equipped with Brebo 4-piston fixed calipers, matching Bosch DPB, intelligent decoupling braking system, providing braking pressure on all wheels, and ESP 10.0, which is responsible for wheel braking force adjustment and pressure control to keep the car body stable. Xiaomi Automobile introduced in Guanwei that if the brake module fails, DPB and ESP are mutually backup; If DPB and ESP fail at the same time, traditional mechanical hydraulic braking can still be used to effectively slow down.

"At present, the vehicle has returned to normal, but it is still based on the attitude of being responsible to the user. The staff indicated to the user that they can support the user’s request for returning the car or changing the car, and at the same time cover the expenses incurred by returning the car. If you change cars, you will be given priority according to the original order number, and you will be compensated for the waiting period. " Wang Hua said.

In response to the problem that the customer service hotline was not connected, Wang Hua said that at that time, it was at the peak of the incoming line, and there were many busy queues, and it was not connected in time. Xiaomi Automobile apologized for this. In this incident, the user-specific service group responded to the needs of users and arranged road rescue support.

In view of the shortage of professional customer service seats, Wang Hua said that recruitment was urgently started in April, and it is expected that the online customer service pick-up rate will be greatly improved by the end of May. SOS is mainly aimed at the response channel of medical rescue for the wounded in vehicle accidents, and the professional platform institutions in the industry cooperate to provide this service; Other car scene services are mainly provided by Xiaomi after-sales service.

Shortly after the release of Wang Hua Weibo, Li Xiaoshuang, vice president of Xiaomi Automobile, forwarded the content with an article "Hope to Know".

A few days ago, a car blogger revealed that the number of locks on Xiaomi SU7 has exceeded 100,000. However, while the sales volume is rising, Xiaomi Automobile may still face the quality control challenge of the first batch of cars off the assembly line.

It is worth mentioning that shortly before the brake failure of Xiaomi SU7, on May 5, the car of Mr. Wen, the owner of SU7 in Xiamen, Fujian, also encountered a suspected quality problem, and the new car he just mentioned was prompted to fail less than 40 kilometers. According to media reports, the cause of the vehicle failure needs to be further analyzed, and it is temporarily impossible to repair.

As of May 13th, Xiaomi Group-W (1810.HK) closed at HK$ 19.36 per share, with a total market value of HK$ 483.1 billion, down slightly by 0.21%.

Original title: Hunan Xiaomi SU7 brake failure? Xiaomi PR admitted: It is indeed a software misidentification.

How cheap is the Pentium pony with an account of 28,900？

2025年4月18日 | admin | C3

Buying a car now is very polarized. More than 300,000 expensive cars are still the favorite of consumers above the middle class. For ordinary consumers, the cheaper the car, the better, and it is better to be cheaper than taking the subway. The cost of car maintenance must be low, and the model must be cheap to go out, but it must be sheltered from the wind and rain, and it is best to give consideration to personalization. How about it?

If you had asked for this three years ago, you would have been beaten. Why do you think so beautifully? But today, three years later, your dream seems to be coming true.

On April 30th, Pentium Pony started the pre-sale, and the pre-sale price range was 28,900-34,900 yuan, and the starting price was cheaper than that of Wuling Hongguang MINIEV at the same level. It is also a pure electric vehicle, with a maximum power of 20kW and a peak torque of 85N·m, matching with lithium iron phosphate battery. The pure electric cruising range of CLTC is 122km and 170km respectively. In terms of size, it is bigger and more spacious than Wuling Hongguang MINIEV. So, do you have a crush?

First of all, the price of this car is less than 30 thousand yuan, and you can have a cruising range of 122km. This version is called Meng Fun Horse. In other words, you can extract colors from the sky, flowers, fruits and oceans at this price. Pentium Pony has six optional car colors: indigo, cheese white, camellia green, peach powder, jasmine white and bubble blue. At the same time, like the 200,000-yuan model, the 6-layer spray paint process is used to ensure the color texture. Don’t think that if we spend less money, we will enjoy less and not exist.

And what else can you buy? It’s a fun car, with cute capsule elements, personalized building block space, game handle buttons, dessert shift knobs, fun pedal symbols and other original ideas. It integrates toys, games and other elements into the interior and exterior design, which is a very cute photo weapon wherever you go.

What will happen inside? Let me tell you, the width of the main driver’s seat is 480mm ahead of its peers, there are also air conditioners that can heat and cool very quickly, and the defrosting function that can complete 82.6% of the defrosting area ahead of its peers in 20 minutes. The intelligence is even more important. The whole system comes standard with leapfrog configuration such as main driving airbag, ramp assist and reversing radar. Listen up, it is standard in the whole system.

Then it’s time to settle accounts. The electricity consumption of Pentium Pony is only 8.8kW·h per 100 kilometers, and the travel cost per kilometer is as low as an astonishing 5 cents. If you calculate according to the number of kilometers you commute to and from 40km kilometers every day, it’s 8 yuan. If you take the subway at this distance, it will probably be around 10 yuan. 10 thousand kilometers a year, 500 yuan for electricity. There is no purchase tax for buying a car, and there is basically no maintenance for raising a car. What are you worried about?

Wenxuan language: cheap and easy to use, close to the people and affordable, this is the tonality that Pentium gives you, Pentium pony.

From tomorrow, these new rules will affect your life and mine.

2025年4月17日 | admin | A1

There are new regulations to promote the development of individual industrial and commercial households.

Li Keqiang, Premier of the State Council of the People’s Republic of China recently signed the the State Council Order, promulgating the Regulations on Promoting the Development of Individual Industrial and Commercial Households, which will take effect on November 1, 2022. The "Regulations" clarify that the government and its relevant departments provide support for individual industrial and commercial households in terms of market subject registration, annual report service, supply of business premises, capital, taxation, finance, social security, entrepreneurial employment, community convenience services, digital development, intellectual property protection, and bail-out assistance. When formulating relevant policies and measures, the government and its relevant departments shall fully listen to the opinions of individual industrial and commercial households and relevant industry organizations, and shall not, in violation of regulations, formulate or implement discriminatory policies and measures against individual industrial and commercial households in terms of qualification licensing, project declaration, government procurement and bidding. No unit or individual may charge individual industrial and commercial households in violation of laws, regulations and relevant provisions of the state or charge them in disguised form, expand the charging scope or raise the charging standard without authorization, raise funds or apportion funds from individual industrial and commercial households, or force individual industrial and commercial households to provide sponsorship or accept paid services.

> > Read in detail: Li Keqiang signed the the State Council Order to promulgate the Regulations on Promoting the Development of Individual Industrial and Commercial Households.

The operation of tank cars with major safety risks is completely prohibited.

The Ministry of Transport, the Ministry of Industry and Information Technology, the Ministry of Public Security and the General Administration of Market Supervision jointly issued the Work Plan for the Management of Tankers of Atmospheric Liquid Dangerous Goods, which standardized the production, registration, use and inspection of tankers of atmospheric liquid dangerous goods, concentrated on rectifying the outstanding problems existing in the operation of tankers, and comprehensively improved the safe operation level of tankers. The "Proposal" clarifies that from November 1, 2022, China will completely ban the operation of tankers with major safety risks.

From November 1st, consumption tax will be levied on e-cigarettes.

The Ministry of Finance, the General Administration of Customs and State Taxation Administration of The People’s Republic of China jointly issued the Announcement on the Collection of Consumption Tax on Electronic Cigarettes, which will take effect on November 1, 2022. The "Announcement" clarifies that e-cigarettes will be included in the scope of consumption tax collection, and e-cigarettes will be added under the heading of tobacco tax. Units and individuals that produce (import) and wholesale electronic cigarettes in People’s Republic of China (PRC) are consumption tax payers. E-cigarettes shall be taxed at an ad valorem rate. The tax rate for the production (import) link is 36%, and the tax rate for the wholesale link is 11%. Taxpayers exporting electronic cigarettes are subject to the export tax refund (exemption) policy. E-cigarettes will be added to the list of imported goods that are not exempt from duty and taxed according to regulations.

@ Driving school coach, you should pay attention to these in future training.

The Ministry of Transport announced the newly revised Regulations on the Management of Motor Vehicle Driver Training, which will take effect on November 1, 2022. The new version of the "Regulations" clarifies that coaches implement a vocational skill grading system. Driving and training institutions are required to sign training contracts with trainees to protect their legitimate rights and interests. It is stipulated that driving and training institutions must carry out relevant training in the recorded teaching venues to reduce problems such as disorderly operation and evasion of supervision. Add requirements for evaluating students’ satisfaction, improve the quality credit evaluation system of driving and training institutions, and improve the quality of business services.

> > Read in detail: Interpretation and full text of the Ministry of Transport’s revision of the Management Regulations on Motor Vehicle Driver Training.

Implementation of Measures of People’s Republic of China (PRC) Customs for Supervision of Transit Goods.

The Measures for the Supervision of Transit Goods of People’s Republic of China (PRC) Customs shall come into force on November 1, 2022. The "Measures" stipulate that ten types of goods are prohibited from crossing the border. It is clear that transit goods shall be subject to customs supervision from entry to exit. Without the approval of the customs, no unit or individual may open, pick up, deliver, ship, exchange, modify, mortgage, pledge, retain, transfer, change the label, use it for other purposes or otherwise dispose of transit goods. Animals and plants, animal and plant products and other quarantine objects shall not be unloaded from the means of transport without customs approval during transit.

> > Read in detail: Measures of People’s Republic of China (PRC) Customs on the Supervision of Transit Goods (Order No.260 of the General Administration of Customs)

List management is fully implemented for tax administrative licensing matters.

Announcement of State Taxation Administration of The People’s Republic of China on the Full Implementation of List Management of Tax Administrative Licensing Matters shall come into force on November 1, 2022. The Announcement makes it clear that the State Administration of Taxation, according to the list of administrative licensing items examined and approved by the State Council, issues a list of tax administrative licensing items that are uniformly implemented nationwide and incorporated into the management of the national administrative licensing management system. The tax authorities at or below the provincial level are not allowed to implement the tax administrative license outside the list. At the same time, the implementation provisions of the "examination and approval of the maximum billing limit of the VAT anti-counterfeiting tax control system" were clarified.

> > Read in detail: Announcement on the full implementation of the list management of tax administrative licensing items.

Implementation of new regulations on food production license examination

The General Administration of Market Supervision revised and promulgated the General Rules for the Examination of Food Production License (2022 Edition), which will take effect on November 1, 2022. The General Principles (2022 Edition) clarifies that the examination of food production license includes the examination of application materials and on-site verification. The verification team shall complete the on-site verification within 5 working days from the date of accepting the on-site verification task. If the on-site verification conclusion is judged as passed, the applicant shall complete the rectification of the problems found in the on-site verification within 1 month from the date of making the on-site verification conclusion, and report the rectification results to its daily supervision department in writing.

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It is related to digital textbooks for primary and secondary schools! Three national standards were implemented in November.

The General Administration of Market Supervision (Standards Committee) issued three national standards: Basic Process of Digital Textbooks Publishing in Primary and Secondary Schools, Metadata of Digital Textbooks in Primary and Secondary Schools, Quality Requirements and Testing Methods of Digital Textbooks in Primary and Secondary Schools, which stipulated the basic process of publishing digital textbooks in primary and secondary schools, put forward the quality requirements for digital textbooks in primary and secondary schools, gave the testing process and testing methods, and put forward an overall plan compatible with education and publishing fields, which was formally implemented on November 1, 2022.

Is there a problem or hidden danger with the drug? Recall according to the new management method

National Medical Products Administration organized the revision of the Measures for the Administration of Drug Recall, which came into force on November 1, 2022. The "Measures" clarify that drug marketing license holders, drug manufacturers, drug trading enterprises and drug users should establish and implement a drug traceability system according to regulations, keep complete purchase and sale records, and ensure the traceability of listed drugs. In the process of implementing the recall, the holder of the drug marketing license shall report the progress of the drug recall to the pharmaceutical supervisory and administrative department of the people’s government of the province, autonomous region or municipality directly under the Central Government every three days, and every seven days. The holder of the drug marketing license shall keep detailed records on the handling of the recalled drugs, and the records shall be kept for 5 years and shall not be less than 1 year after the drug is valid.

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Eating a stuffed tooth may be five kinds of dental diseases. There are seven tips for tooth protection.

2025年4月16日 | admin | C3

　　Editor’s note:With the improvement of living standards, health has become our most concerned topic. What is healthy food? How to prevent physical diseases in life? This has become the focus of attention. People’s Health Network launched the column "Jintai Health Garden" to take stock of the most healthy lifestyle for you and take you into the health garden.

　　Eating teeth may be caused by five kinds of dental diseases.

　　Stuffing one’s teeth while eating is a trivial matter in life, and many people don’t care. As everyone knows, frequent tooth plugging is actually a harbinger of some dental diseases.

　　Gingival atrophy With the increase of age or periodontitis, the gums will gradually shrink, leading to the widening of the teeth and the easy embedding of food.

　　When wisdom teeth sprout, because of the lack of space, they often occupy the space of adjacent teeth and easily get stuck in food.

　　Dental caries If dental caries are not treated in time, a "wormhole" will be formed, and food will be embedded in the hole, causing tooth plugging.

　　The missing teeth are missing, dislocated and uneven, which may lead to eating.

　　Tooth wear After tooth wear, the edges or tips of teeth will become sharp, and the fibers in food will be squeezed into the teeth when chewing.

　　Dental floss should be used first after filling. If the filling is serious, you should go to the hospital in time and deal with it appropriately according to the situation. Such as filling cavities, extracting wisdom teeth, inlay or periodontal treatment, can effectively solve the problems of tooth plugging.

　　You should brush your teeth before drinking water after getting up in the morning. You should not brush your teeth immediately after meals.

　　Many people have the habit of drinking a glass of water when they get up in the morning. Do you brush your teeth or drink water first? Experts say that you should brush your teeth before drinking water after getting up in the morning to avoid getting sick from your mouth. At the same time, you should not brush your teeth immediately after meals, otherwise your teeth will be damaged.

　　Wu Jie, deputy director of the Department of Pediatric Stomatology of Nanjing Maternal and Child Health Hospital, explained that people’s bodies are still digesting food when they sleep. The oral cavity provides a warm and humid environment, which is conducive to the growth of bacteria. After a night of "cultivation" in the hotbed, a large number of bacteria remain in the oral cavity. Therefore, after getting up in the morning, before supplementing any food, you must brush your teeth first to ensure that your mouth is clean and avoid illness from entering your mouth. After brushing your teeth, you can replenish water in time.

　　Many people brush their teeth immediately after eating. In fact, it is harmful to their teeth. Wu Jie said that food residue is stuck on the teeth after meals. If you brush your teeth immediately, it will push the "acid" into the depths of the enamel, even the dentin under the enamel. Brushing your teeth immediately after a meal can not only protect your teeth, but will hurt them. "Generally speaking, it is not recommended to brush your teeth within half an hour to an hour after eating. You should wait until the pH in your mouth reaches a balance before brushing your teeth."

　　As for whether the toothpaste needs to be dipped in water before brushing, Wu Jie said that ordinary toothpaste dipped in water or brushed directly can play a role in cleaning the mouth. For desensitized toothpaste or whitening toothpaste, it is not recommended to dip in water before brushing your teeth. These toothpastes themselves have active ingredients, which are likely to be destroyed after dipping in water, and the effect will be greatly reduced.

　　There are seven tips for tooth protection: cleaning floss and chewing carrots … …

　　1. Chew more apples and carrots. Crispy food, like a toothbrush, helps to remove tooth stains. Usually, you can eat more foods containing calcium, vitamin D and omega-3, which can strengthen your teeth and gums, such as green leafy vegetables, citrus fruits, salmon and dairy products.

　　2. Choose toothpaste containing baking soda. Mccalin suggests brushing your teeth at least twice a day, preferably after every meal, which helps to remove food and plaque between your teeth and gums. Weak alkaline baking soda can effectively neutralize harmful acids, help remove plaque, strengthen tooth enamel, and play a whitening effect. Can be used in conjunction with soft hair electric toothbrush to deeply clean each tooth.

　　Step 3 floss. Floss can clean the gaps between teeth and gums that toothbrushes can’t reach, and prevent tooth decay and gum diseases. Mccalin suggested flossing before brushing your teeth after three meals a day.

　　4. quit smoking. Any tobacco product will cause oral tissue damage and stain teeth. Tobacco can also weaken the immune system, easily lead to gum infection, making it difficult for teeth and gums to recover after treatment.

　　Step 5 use mouthwash. Using over-the-counter mouthwash every day helps to remove food residues, which helps to reduce dental plaque and prevent or reduce the risk of gingivitis.

　　6. Go to the dentist twice a year. Dentists can find the symptoms of early gum disease, treat it in time before the condition is serious, and completely remove the calculus deposited on teeth by calcification.

　　7. Drink more milk and water. More than 95% of calcium in human body exists in bones and teeth. Drinking milk can supplement calcium and strengthen teeth and bones. Drinking plenty of water can wash away food and bacteria, and prevent them from sticking together after meals, producing acid and eroding teeth. If you can’t brush your teeth or floss after meals, drinking a cup of warm water can also help keep your mouth healthy.

　　Brushing your teeth well can prevent senile dementia.

　　Sticking to correct brushing and maintaining oral hygiene can not only prevent tooth decay, help maintain good chewing function and gastrointestinal function, but also prevent senile dementia.

　　Gingivitis is a common oral disease among the elderly, which is mostly caused by Porphyromonas gingivalis. Peter Medell of the Research Laboratory of the Department of Clinical Sciences, University of Bergen, Norway, and his team found evidence based on DNA through experiments, confirming that Porphyromonas gingivalis can transfer from the oral cavity to the brain. The harmful enzymes produced by Porphyromonas gingivalis will destroy nerve cells in the brain, cause memory loss in the elderly and eventually lead to senile dementia. The research team observed and tested 53 senile dementia patients, and found this harmful enzyme in 96% patients. It can be seen that keeping teeth healthy and away from Porphyromonas gingivalis is of great significance to protect the brain and maintain cognitive function.

　　There are six reasons for bleeding when brushing teeth.

　　Gingivitis When dental plaque and bacteria causing tooth decay gather on the teeth, the gums will become inflamed. Because there are almost no symptoms, it is easy to be ignored unless the gums bleed when brushing or flossing. If left untreated, gingivitis can lead to periodontal disease.

　　Smokers have a higher risk of gum bleeding. Inhaled smoke will leave irritating toxins on teeth, which are difficult to remove by brushing your teeth. These unhealthy substances can lead to bleeding gums.

　　Malnutrition and maintaining a healthy lifestyle are important oral hygiene defense measures. A balanced and diversified diet is not only the key to maintaining good health, but also the key to promoting oral health.

　　The changes of hormone secretion function during menstruation and pregnancy will increase the chance of gingival bleeding. Some women will suffer from estrogen-related gingivitis during menstruation. Changes in hormones during pregnancy can also increase the risk of gingivitis or periodontitis.

　　Poor oral hygiene, too hard brushing, not brushing at all and forgetting to floss your teeth will cause gum bleeding. Gingiva is a rather soft tissue. If you hurt it with a bristle toothbrush, your gums will swell and bleed. Failure to brush your teeth will cause plaque and food debris to accumulate, generate acid and affect your gums.

　　Taking certain drugs, some prescription drugs will increase the risk of gum bleeding. Antiepileptic drugs can cause abnormal gingival swelling, antihistamines, sedatives, antidepressants and antipsychotics can cause decreased saliva secretion and dry mouth, and food residues and bacteria can not be washed away, thus causing gingivitis.

　　Toothbrushes have five helpers: flossing, cleaning teeth, and tooth powder can whiten teeth.

　　Zhao Qiang, director of the Stomatological Center of Aviation General Hospital of China Medical University, said that there are five kinds of cleaning tools besides ordinary toothbrushes, which can be used according to different people and different needs.

　　Floss. In recent years, dental floss has become a necessity for people to clean their teeth daily, which can be roughly divided into dental floss rolls and dental floss sticks. When using dental floss roll, the operator can adjust the angle with his fingers to make it fit the tooth surface better, but the technical requirements are also higher. The dental floss stick has a handle to hold, which is more convenient for cleaning the front teeth. It should be noted that there are many bacteria on the used dental floss, which cannot be washed with clean water and cannot be reused.

　　Tooth washer. Plaque can only be removed by physical friction such as brushing teeth. However, the plaque hidden in the teeth and gingival sulcus is difficult for bristles to reach. If not cleaned in time, these plaques will cause pain, bleeding gums and even loose teeth. The main function of the tooth washer is to help brush teeth and eliminate dental plaque that is difficult to clean. Some merchants claim that the tooth washer can replace tooth washing. It should be reminded that the tooth washer has no effect on the formed dental calculus, so it can’t replace the tooth washing, nor can it remove the food fiber between the teeth, nor can it replace the function of dental floss moving and pulling.

　　Interdental brush. Periodontal disease, tooth displacement and other reasons will increase the gap between teeth and lead to food impaction. Both interdental brush and dental floss can effectively remove food or plaque in the teeth. However, the brush head of interdental brush is thicker than dental floss, which is not suitable for people with small teeth. In addition, the interdental brush can’t clean the other three surfaces outside the adjacent surface of the teeth and the gingival margin. Therefore, it is recommended to use the toothbrush first and then the interdental brush, and rinse your mouth in time after each use.

　　Tooth powder Tooth powder can remove bacteria and stains on the surface of teeth and whiten teeth in a short time, which is suitable for alternate use with toothpaste. Its main components are natural antibacterial polyphenols and vitamin D, etc., and it is easily soluble in water and can soak the corners of the mouth. However, tooth powder has the function of decalcification, and it is acidic and has large particles, which is easy to damage the gums and cause inflammation of oral tissues. People with oral diseases should not use it.

　　Toothpaste Toothpaste can really whiten teeth in a short time, but it can’t fundamentally solve the color and cleaning problems of teeth, so it is not recommended to use it for a long time. Its main principle is to discolor the teeth and lighten the color of yellow teeth and black teeth, but the discoloring agent will stimulate the nerve and blood vessels at the gingival margin, which may lead to allergies, destroy the enamel structure and make the tooth surface rough. In addition, patients with severe periodontal disease must be cured before whitening; Teeth of teenagers and pregnant women are sensitive and easy to cause discomfort, and it is not recommended. (People’s Health Network is integrated from Life Times, Health Times, Guangzhou Daily, Xinhuanet)